Neighbours will grace Australian TV screens for the last time on Thursday, July 28, with a star-studded line up including Margot Robbie, Kylie Minogue, Jason Donovan, Jesse Spencer, Delta Goodrem and more.

From Scott and Charlene's wedding, Stingray's death and Toadie and Dee's wedding through to Delta Goodrem's musical performance, Karl's affair and Harold's return - there is no doubt the show had many memorable moments.

Sydney-siders and those from NSW's Hunter region had their say on some of the shows biggest plotlines.

Stephen and Nedene Barretto said Scott and Charlene's wedding was a Neighbours highlight.

"As boring as it is, Charlene and Scott getting married is our fondest memory," Mrs Barretto said.

"The storylines aren't great, God love them, but it's sad that it's ending."

Kylie Minogue and Jason Donovan will return to the small screen as Charlene and Scott Robinson for the show's last episode.

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Their characters became so beloved that more than 20 million people across Australia and the UK watched their wedding episode when it aired in 1987 and 1988, respectively.

Their wedding episode was an iconic one for Deb Saville too.

"I remember all the weddings like Kylie's - and Paul got married a couple of times and Toadie got married a couple times," she said.

"It's the weddings I remember mostly."

For Carson Kobold, it was iconic characters that jogged his memory.

"I remember the hotel mogul, I think his name was Paul and the old guy, Harold, who played the tuba," he said.

Andrea Kendros had more vivid memory of his favourite Neighbours moment.

"1997, when Karl kissed Sarah Beaumont and then when Susan found out and then she slapped him in the face," he said.

The Neighbours 90-minute final episode will air at 7.30pm, Thursday, July 28 on 10 and 10 Peach.