Monarchs in the Hunter - curated by Jan Hugo at her Nulkaba home - is one of, if not the biggest collection of British Royal Family memorabilia in Australia, boasting about 10,000 pieces.

Ms Hugo and her husband David have hosted thousands of visitors since they opened the museum in 2013.

But the business - which mainly caters to seniors - has taken a huge hit in the wake of COVID-19.

Just two groups have visited since March last year, and Ms Hugo says she is considering closing the museum down, and will host a last-chance open day this Saturday.

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"Our business was retirement villages, nursing homes and seniors clubs, and they just aren't doing the trips," she said.

"It just isn't worth the insurance.

"People think because it's in our home that we don't have those costs, but we're like any other business - we just don't pay rent.

"The future is unclear.

"I'm really disappointed, but that's the time that we're living in.

"I can understand the elderly not wanting to come out."

Along with people staying at home, Ms Hugo said last year's border closures also hit the business hard, as South Australia and Victoria were their biggest customers.

The Hugos opened the museum in 2013 after the birth of Prince George, when their collection gained national media attention.

They hosted on average two bus groups a week (up to 50 people at a time), and even more during the summer months, when the Hunter Valley Gardens Christmas Lights Spectacular was on.

Ms Hugo said she has a couple of groups booked in for December this year, but apart from that, this Saturday's open day may be the last chance the public has to view the collection.

It boasts everything from a King George III coin from 1806, to coffee mugs commemorating Prince Philip's passing in April this year.

If she does close down the museum as intended, Ms Hugo says she will continue to collect.

"I will never stop collecting. I will keep doing it until they carry me out feet-first!" she said.

"It's just what I do - I collected for a long time before we opened up."

The open day will start at 10.30am Saturday. Cost is $15 per person, including morning tea.

Seats are limited and bookings are essential by calling Jan on 4990 4224 or 0402 841 797.