According to Hunter New England Local Health District, additional people aged 40 to 49 can now register for the Pfizer vaccine at John Hunter Hospital or Tamworth Hospital.

The NSW Government has announced it is "accelerating" the rollout of the COVID-19 vaccine with 25 Pfizer sites across the state set to take bookings for people aged 40 to 49 from May 24.

NSW Health said the sites, spread across greater Sydney and rural and regional NSW, are aimed at ensuring as many people as possible have access to the vaccine.

Around 23,500 people aged between 40 and 49 have already been invited to book a vaccine at a NSW Health clinic, with 12,000 people already booked for the Pfizer jab.

Premier Gladys Berejiklian said it was great to see such a positive response from the public to register for the vaccine.

"I want to thank the more than 120,000 people aged 40 to 49 who have already registered their interest to receive the Pfizer jab. We are working hard to ensure you receive the vaccine as soon as possible," Ms Berejiklian said.

Health Minister Brad Hazzard said NSW Health has worked hard to expand its Pfizer footprint across NSW.

"We're making it easier for people right across NSW to access COVID vaccines as quickly as possible," Mr Hazzard said.

"The more people vaccinated sooner in our state the stronger our defence against this extremely dangerous virus."

People aged 40-49 can register for the Pfizer vaccine here: nsw.gov.au/. People will be contacted when a booking is available.

Tamworth and Port Macquarie Hospitals will also be administering Pfizer to that age group, with Armidale, Muswellbrook and Manning Hospitals to progressively start offering the vaccine throughout June.